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Three landmark clinical diabetes studies all concluded that maintaining mean blood glucose (MBG) levels at or about normal levels can reduce the risk for developing diabetes complications such as eye, kidney and nerve disease by as much as 72%. Maintaining "Tight Control" is important in all forms of diabetes. Reduce your risk for complications by routinely monitoring your A1c level.
AccuBase A1c Test Kit FDA approved for over-the-counter (OTC) use (No Prescription required). Patent Pending Multi-Method Laboratory Analysis Procedure. The AccuBase A1c Test uses a unique and highly specialized multi-method laboratory analysis (HPLC-IE/BA) to evaluate your A1c level. The two (2) step process includes a screening step to detect hemoglobin variants and/or disturbed erythrocyte kinetics (DEK) by HPLC-Ion Exchange (IE). The second step includes the use of an interference -free procedure HPLC-Boronate Affinity (BA), that provides an A1c value free of possible interferences including chemically modified derivatives. This multi-method approach provides the most comprehensive evaluation of individual hematology surrounding A1c as the most recent inference of glycemic control by any laboratory or method available in the U.S. A proper A1c determination should always include the evaluation of the individuals Red Blood Cells at the time of A1c measurement. The AccuBase A1c multi-method analysis does this and more. Healthcare professional and patients alike should remember to: "Treat the patient not just the A1c number" Treating the patient includes evaluating red blood cells and screening for any possible hemoglobin variants. Extremely high or low A1c values should always be evaluated for the presence of possible abnormal hemoglobins. <4.0% or >15.0% The AccuBase A1c Test Kit is a highly accurate test (CV's < 1.0%) capable of detecting abnormal and/or silent hemoglobin variants such as hemoglobin S, and C and F and over 850 others. Each sample is first screened for presence of abnormal hemoglobins and/or disturbed erythrocyte kinetics (abnormal age or volume of red blood cells) Example; anemia (which can falsely lower the A1c value). Individuals with long-standing diabetes may present with a condition called erythropoietin (EPO) deficiency. EPO deficiency and/or anemia are considered serious conditions requiring appropriate medical intervention. DEK can adversely affect the A1c answer and each sample should be screened for the presence of DEK. Estimates report that over 650,000 Black Americans with diabetes are know to have the Sickle Cell Trait (Hb "S, C or F") "Don't be fooled by claims of accuracy when an A1c method and/or disposable monitoring device has CV's (coefficient of variation) greater than 2.0% or can not detect an abnormal hemoglobin" "An A1c method and/or monitoring device with a CV of 7.0 % could mean that if your actual A1c level was 6.5% it could be reported anywhere from 5.0% to 8.0% providing false and/or misleading therapeutic information," not to mention the impact of an abnormal hemoglobin on the A1c value that the particular method or device is incapable of detecting. Each AccuBase A1c sample is analyzed by an HPLC-IE procedure with resulting printed Chromatogram as shown below. Our laboratory staff is available to discuss individual chromatograms with your physician and/or medical personnel. The graph below (left) demonstrates a normal chromatogram with no hemoglobin variants present and a normal A1c level. The Chromatogram to the (right) demonstrates an highly elevated level of hemoglobin F (25.6%). This elevated level of Hb F resulted in a sub-normal A1c value of 3.2%. Normal range of A1c assay (4.2% - 6.0%). Unless you have been screened for hemoglobin variants you would not know you carry the hereditary persistent variant, or be aware of its associated impact on your A1c level.
 Increased levels of Hemoglobin F may represent an increased risk for SIDS in infants, and
may represent as association in various types of leukemia and/or solid
tumors. Mothers that smoke or have been exposed to environmental pollution
during pregnancy may have a much higher
level of Hb F in the baby which may increase the risk of SIDS in the
newborn.
The AccuBase A1c Test Kit has several unique advantages, call us for further details... 888.872.2443 When Accuracy Counts, Count on the AccuBase A1c Test Kit
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