Translating the HbA1c value into Estimated Average Glucose (eAG)
Objective: The HbA1c (A1c assay, expressed as the percent (%) of hemoglobin that is glycated (bound to hemoglobin) measures chronic glycemia and is widely used to judge the efficacy of diabetes treatment and therapy adjustment. While day-to-day management is guided by self-monitoring of blood glucose (capillary) concentrations (measured in mg/dl or mmol/l).
Results: Linear regression analysis between HbA1c (A1c) and average glucose (AG) values provided the tightest correlation (AG mg/dl = 28.7 X A1c - 46.7, R 2 = 0.84 P < 0.0001), allowing calculation of an estimated average glucose (eAG) for A1c values. The linear regression analysis did not differ significantly across subgroups based on age, sex, diabetes type, race/ethnicity, or smoking status.
Conclusion: A1c levels can be expressed as eAG for most patients with Type 1 and Type 2 diabetes.
Converting HbA1c to
Estimated Average Glucose
Based on the results of the A1c - Derived Daily Glucose (ADAG) study. +
|
HbA1c (%) |
eAG (mg/dl) |
| 4.0 |
68 |
| 5.0 | 97 |
| 6.0 | 126 |
| 7.0 | 154 |
| 8.0 | 182 |
| 9.0 | 211 |
| 10.0 | 240 |
| 11.0 | 269 |
| 12.0 | 297 |
eAG results should be interpreted and target levels set by a healthcare professional. The American Diabetes Association (ADA) recommends maintaining A1c levels below 7.0%.
To perform a A1c to eAG conversion, click on the following link: http://professional.diabetes.org/glucosecalculator.aspx
To view a Power Point presentation on the eAG, click the link: http://professional.diabetes.org/Content/eAGPowerpointSlides.ppt
Links: http://www.aacc.org/publications/cln/2008/october/Pages/cover1_1008.aspx
http://professional.diabetes.org/glucosecalculator.aspx